Kynurenines in Parkinson's disease: Therapeutic perspectives

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a chronic progressive neurodegenerative disorder the pathomechanism of which is not yet fully known. With regard to the molecular mechanism of development of the disease, oxidative stress/mitochondrial impairment, glutamate excitotoxicity and neuroinflammation are certainly involved. Alterations in the kynurenine pathway, the main pathway of the tryptophan metabolism, can contribute to the complex pathomechanism. There are several possibilities for therapeutic intervention involving targeting of this altered metabolic route. The development of synthetic molecules that would shift the altered balance towards the achievement of neuroprotective effects would be of great promise for future clinical studies on PD.

Original languageEnglish
Pages (from-to)275-283
Number of pages9
JournalJournal of neural transmission
Volume119
Issue number2
DOIs
Publication statusPublished - Feb 1 2012

Keywords

  • Excitotoxicity
  • Kynurenines
  • Neuroinflammation
  • Neuroprotection
  • Oxidative stress
  • Parkinson's disease
  • Therapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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