Kynurenines and other novel therapeutic strategies in the treatment of dementia

Zsofia Majlath, Janos Tajti, Laszlo Vecsei

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Dementia is a common neuropsychological disorder with an increasing incidence. The most prevalent type of dementia is Alzheimer's disease. The underlying pathophysiological features of the cognitive decline are neurodegenerative processes, a cerebrovascular dysfunction and immunological alterations. The therapeutic approaches are still limited, although intensive research is being conducted with the aim of finding neuroprotective strategies. The widely accepted cholinesterase inhibitors and glutamate antagonists did not meet expectations of preventing disease progression, and research is therefore currently focusing on novel targets. Nonsteroidal anti-inflammatory drugs, secretase inhibitors and statins are promising drug candidates for the prevention and management of different forms of dementia. The kynurenine pathway has been associated with various neurodegenerative disorders and cerebrovascular diseases. This pathway is also closely related to neuroinflammatory processes and it has been implicated in the pathomechanisms of certain kinds of dementia. Targeting the kynurenine system may be of therapeutic value in the future.

Original languageEnglish
Pages (from-to)386-397
Number of pages12
JournalTherapeutic Advances in Neurological Disorders
Volume6
Issue number6
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Alzheimer's disease
  • dementia
  • kynurenine
  • neuroprotective agents

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology

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