Kynurenines and multiple sclerosis: The dialogue between the immune system and the central nervous system

Cecilia Rajda, Zsófia Majláth, Dániel Pukoli, László Vécsei

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Multiple sclerosis is an inflammatory disease of the central nervous system, in which axonal transection takes place in parallel with acute inflammation to various, individual extents. The importance of the kynurenine pathway in the physiological functions and pathological processes of the nervous system has been extensively investigated, but it has additionally been implicated as having a regulatory function in the immune system. Alterations in the kynurenine pathway have been described in both preclinical and clinical investigations of multiple sclerosis. These observations led to the identification of potential therapeutic targets in multiple sclerosis, such as synthetic tryptophan analogs, endogenous tryptophan metabolites (e.g., cinnabarinic acid), structural analogs (laquinimod, teriflunomid, leflunomid and tranilast), indoleamine-2,3-dioxygenase inhibitors (1MT and berberine) and kynurenine-3-monooxygenase inhibitors (nicotinylalanine and Ro 61-8048). The kynurenine pathway is a promising novel target via which to influence the immune system and to achieve neuroprotection, and further research is therefore needed with the aim of developing novel drugs for the treatment of multiple sclerosis and other autoimmune diseases.

Original languageEnglish
Pages (from-to)18270-18282
Number of pages13
JournalInternational journal of molecular sciences
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 6 2015

Keywords

  • 3-dioxygenase
  • Indoleamine-2
  • Kynurenine pathway
  • Multiple sclerosis

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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