Kynurenic acid and its analogs are beneficial physiologic attenuators in bdelloid rotifers

Zsolt Datki, Zita Galik-Olah, Zsuzsanna Bohar, Denes Zadori, F. Fülöp, I. Szatmári, Bence Galik, J. Kálmán, L. Vécsei

Research output: Contribution to journalArticle

Abstract

The in vivo investigation of kynurenic acid (KYNA) and its analogs is one of the recent exciting topics in pharmacology. In the current study we assessed the biological effects of these molecules on bdelloid rotifers (Philodina acuticornis and Adineta vaga) by monitoring changes in their survival and phenotypical characteristics. In addition to longitudinal (slowly changing) markers (survival, number of rotifers alive and body size index), some dynamic (quickly responding) ones (cellular reduction capacity and mastax contraction frequency) were measured as well. KYNA and its analogs increased longevity, reproduction and growth, whereas reduction capacity and energy-dependent muscular activity decreased conversely. We found that spermidine, a calorie restriction mimetic, exerted similar changes in the applied micro-invertebrates. This characterized systemic profile evoked by the above-mentioned compounds was named beneficial physiologic attenuation. In reference experiments, using a stimulator (cyclic adenosine monophosphate) and a toxin (sodium azide), all parameters changed in the same direction (positively or negatively, respectively), as expected. The currently described adaptive phenomenon in bdelloid rotifers may provide holistic perspectives in translational research.

Original languageEnglish
Article number2171
JournalMolecules
Volume24
Issue number11
DOIs
Publication statusPublished - Jun 10 2019

Fingerprint

Kynurenic Acid
attenuators
cyclic AMP
pharmacology
analogs
invertebrates
sodium azides
Sodium Azide
acids
Translational Medical Research
Spermidine
biological effects
Body Size
Invertebrates
Cyclic AMP
markers
contraction
Reproduction
constrictions
attenuation

Keywords

  • Bdelloid rotifer
  • Kynurenic acid
  • Mastax
  • Metabolism
  • Physiology
  • Survival

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Kynurenic acid and its analogs are beneficial physiologic attenuators in bdelloid rotifers. / Datki, Zsolt; Galik-Olah, Zita; Bohar, Zsuzsanna; Zadori, Denes; Fülöp, F.; Szatmári, I.; Galik, Bence; Kálmán, J.; Vécsei, L.

In: Molecules, Vol. 24, No. 11, 2171, 10.06.2019.

Research output: Contribution to journalArticle

Datki, Zsolt ; Galik-Olah, Zita ; Bohar, Zsuzsanna ; Zadori, Denes ; Fülöp, F. ; Szatmári, I. ; Galik, Bence ; Kálmán, J. ; Vécsei, L. / Kynurenic acid and its analogs are beneficial physiologic attenuators in bdelloid rotifers. In: Molecules. 2019 ; Vol. 24, No. 11.
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