Kisspeptin modulates pain sensitivity of CFLP mice

Krisztina Csabafi, Zsolt Bagosi, Éva Dobó, Júlia Szakács, Gyula Telegdy, Gyula Szabó

Research output: Contribution to journalArticle

Abstract

Kisspeptin, a hypothalamic neuropeptide, is a member of the RF-amide family, which have been known to modify pain sensitivity in rodents. The aim of the present study was to investigate the effect of kisspeptin-13 (KP-13), an endogenous derivative of kisspeptin, on nociception in adult male and female CFLP mice and the possible interaction of KP-13 with morphine on nociception. Mice were injected with different doses of KP-13, 30, 60 and 120 min after of which the nociceptive sensitivity were assessed via the tail-flick test. To investigate the receptor involved in the mediation a kisspeptin receptor antagonist (KP-234) pretreatment was applied before KP-13 administration. Furthermore, we investigated the effect of KP-13 on the acute antinociceptive effect of morphine, on acute morphine tolerance and on naloxone-precipitated withdrawal. Last, the Von Frey test was used in order to assess KP-13′s effect on mechanical nociception. Our results showed that KP-13 decreased the nociceptive threshold of both males and females independent of sex, which was prevented by KP-234. Furthermore, KP-13 treatment depressed the acute antinociceptive effect of morphine and attenuated the development of morphine tolerance. KP-13 also induced a mechanical hypersensitivity. These data underlie kisspeptin's hyperalgesic action and argues for the role of kisspeptin receptor 1 in the mediation of its action. Furthermore, our results suggest that central KP-13 administration can modify the acute effects of morphine.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalPeptides
Volume105
DOIs
Publication statusPublished - Jul 2018

Keywords

  • Hyperalgesia
  • Kisspeptin
  • Morphine
  • Nociception
  • RF-amides

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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  • Cite this

    Csabafi, K., Bagosi, Z., Dobó, É., Szakács, J., Telegdy, G., & Szabó, G. (2018). Kisspeptin modulates pain sensitivity of CFLP mice. Peptides, 105, 21-27. https://doi.org/10.1016/j.peptides.2018.04.018