Kinetics of inflammatory markers following cancer-related bowel and liver resection

Sándor Márton, János Garai, Valééria Molnár, Vera Juhász, L. Bogár, T. Kőszegi, Boglárka Falusi, Subhamay Ghosh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. Macrophage migration inhibitory factor (MIF) was originally described as a cytokine that inhibits migration of macrophages at the site of inflammation. Subsequently it was also identified as a stress-induced hormone released from the anterior pituitary lobe in response to some pro-inflammatory stimuli like endotoxins and tumour necrosis factor (TNF-α). Aim. To compare postoperative changes in serum MIF levels of patients undergoing bowel and liver resections. It has clinical relevance to describe the kinetics of this crucial mediator of systemic inflammation in surgery. Methods. A total of 58 patients were studied over 4 years. Group A (28 patients) underwent only hepatic resection without enterotomy. Group B (30 patients) had bowel resection with enterotomy. MIF, IL-1β, IL-8, prealbumin, albumin, α1-glycoprotein, fibrinogen, and C-reactive protein levels were measured preoperatively, immediately following surgery, and postoperatively for three consecutive days. To evaluate organ functions, multiple organ dysfunction score was used. Results. A significantly higher level of MIF (4,505 pg/mL) was found in group A when compared to that of group B immediately following surgery. Other parameters monitored in this study were not statistically different between the two groups. Conclusion. Higher elevations in MIF levels with liver resections, compared to bowel resections, might be attributable to MIF release from damaged liver cells. The presumably minimal endotoxin exposure during bowel surgery was either insufficient or inefficient to induce relevant MIF elevations in our patients. To fully delineate implications of this finding further studies are needed.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalUpsala Journal of Medical Sciences
Volume116
Issue number2
DOIs
Publication statusPublished - May 2011

Fingerprint

Liver
Neoplasms
Endotoxins
Organ Dysfunction Scores
Macrophage Migration-Inhibitory Factors
Inflammation Mediators
Prealbumin
Anterior Pituitary Gland
Interleukin-8
Interleukin-1
C-Reactive Protein
Fibrinogen
Albumins
Tumor Necrosis Factor-alpha
Macrophages
Hormones
Cytokines
Inflammation
Serum
glycoprotein gC, herpes simplex virus type 1

Keywords

  • C-reactive protein
  • endotoxin
  • macrophage migration inhibitory factor
  • procalcitonin
  • tumour necrosis factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kinetics of inflammatory markers following cancer-related bowel and liver resection. / Márton, Sándor; Garai, János; Molnár, Valééria; Juhász, Vera; Bogár, L.; Kőszegi, T.; Falusi, Boglárka; Ghosh, Subhamay.

In: Upsala Journal of Medical Sciences, Vol. 116, No. 2, 05.2011, p. 124-128.

Research output: Contribution to journalArticle

Márton, Sándor ; Garai, János ; Molnár, Valééria ; Juhász, Vera ; Bogár, L. ; Kőszegi, T. ; Falusi, Boglárka ; Ghosh, Subhamay. / Kinetics of inflammatory markers following cancer-related bowel and liver resection. In: Upsala Journal of Medical Sciences. 2011 ; Vol. 116, No. 2. pp. 124-128.
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