Kinetics of fumonisin B1 in pigs and persistence in tissues after ingestion of a diet containing a high fumonisin concentration

Judit Szabó-Fodor, László Kametler, Roland Pósa, Rene Mamet, Veronika Rajli, Johann Bauer, Péter Horn, Ferenc Kovács, Melinda Kovács

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The absorption, distribution and elimination of fumonisin B 1 (FB 1) and its metabolites was investigated in pigs. For the determination of the absorption and biotransformation of FB 1, T-cannula were implanted into the distal part of experimental pigs' ileum and the total urine and faeces moiety was collected during the toxin feeding (45 mg FB 1/kg diet, duration: 10 days) and in the subsequent elimination period (10 days). At the end of trial several organs, muscle and fat samples were also collected. The accumulative absorption of fumonisin B 1 was 4%. In the chymus, the FB1 conversion to aminopentol (totally hydrolysed FB 1; AP 1) and partially hydrolysed FB 1 (PHFB 1) was 1% and 3.9%, respectively. Derivatives of FB 1 were mostly accumulated in the liver and kidney, while in negligible concentration could be detected in the muscle and fat samples. In the organs the efficacy of the FB 1 to AP 1 and PHFB 1 conversion was 30% and 20%, respectively. In the faecal content the main hydrolised product was PHFB 1 (47%), with 12% of AP 1. 1.5% of the FB1 quantity taken up was excreted with the urine, about 35% in hydrolyzed form. Detectable amounts of FB 1 and its metabolites were measured in most of the organs, in faeces and urine even 10 days after the feeding of the noncontaminated diet. As a general conclusion, the intestinal microbiota of pigs is able to transform the intact FB 1 to a similarly toxic substance (partially hydrolyzed FB 1) or to a more toxic metabolite (aminopentol).

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalCereal Research Communications
Volume36
Issue numberSUPPL. 6
DOIs
Publication statusPublished - Dec 1 2008

Keywords

  • Fumonisin B1
  • Fusarium verticillioides
  • Metabolism

ASJC Scopus subject areas

  • Physiology
  • Agronomy and Crop Science
  • Genetics

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