Az alumínium felszívódásának és szérumszintjének kinetikája krónikus veseelégtelenségben.

Translated title of the contribution: Kinetics of aluminum absorption and serum concentration in chronic renal insufficiency

Z. Sárszegi, K. Jobst, J. Nagy

Research output: Contribution to journalArticle


After administration of a single dose of an aluminium containing antacid (Tisacid) to eight non dialysis patients in various stages of chronic renal insufficiency, the kinetics of serum aluminium absorption was studied. Serum aluminium peaked at two points of time, aluminium absorption being biphasic in renal patients comparing with monophasic kinetic in controls. At the same time, already at 24 hrs after Tisacid ingestion, the aluminium concentration was almost twice as high as initially even in mild renal insufficiency. These results are at variance with the rapidly reversible, monophasic aluminium absorption observed earlier in healthy subjects and in non-renal patients with duodenal ulcer. To ward off complications, a strong warning is given against administration of any aluminium-containing medicament or food to subjects with reduced renal function.

Original languageHungarian
Pages (from-to)1915-1917
Number of pages3
JournalOrvosi hetilap
Issue number35
Publication statusPublished - Aug 27 2000


ASJC Scopus subject areas

  • Medicine(all)

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