Az alumínium felszívódásának és szérumszintjének kinetikája krónikus veseelégtelenségben.

Translated title of the contribution: Kinetics of aluminum absorption and serum concentration in chronic renal insufficiency

Z. Sárszegi, K. Jobst, J. Nagy

Research output: Contribution to journalArticle

Abstract

After administration of a single dose of an aluminium containing antacid (Tisacid) to eight non dialysis patients in various stages of chronic renal insufficiency, the kinetics of serum aluminium absorption was studied. Serum aluminium peaked at two points of time, aluminium absorption being biphasic in renal patients comparing with monophasic kinetic in controls. At the same time, already at 24 hrs after Tisacid ingestion, the aluminium concentration was almost twice as high as initially even in mild renal insufficiency. These results are at variance with the rapidly reversible, monophasic aluminium absorption observed earlier in healthy subjects and in non-renal patients with duodenal ulcer. To ward off complications, a strong warning is given against administration of any aluminium-containing medicament or food to subjects with reduced renal function.

Original languageHungarian
Pages (from-to)1915-1917
Number of pages3
JournalOrvosi Hetilap
Volume141
Issue number35
Publication statusPublished - Aug 27 2000

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Aluminum
Chronic Renal Insufficiency
Serum
Kidney
Antacids
Duodenal Ulcer
Renal Insufficiency
Dialysis
Healthy Volunteers
Eating
Food

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az alumínium felszívódásának és szérumszintjének kinetikája krónikus veseelégtelenségben. / Sárszegi, Z.; Jobst, K.; Nagy, J.

In: Orvosi Hetilap, Vol. 141, No. 35, 27.08.2000, p. 1915-1917.

Research output: Contribution to journalArticle

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abstract = "After administration of a single dose of an aluminium containing antacid (Tisacid) to eight non dialysis patients in various stages of chronic renal insufficiency, the kinetics of serum aluminium absorption was studied. Serum aluminium peaked at two points of time, aluminium absorption being biphasic in renal patients comparing with monophasic kinetic in controls. At the same time, already at 24 hrs after Tisacid ingestion, the aluminium concentration was almost twice as high as initially even in mild renal insufficiency. These results are at variance with the rapidly reversible, monophasic aluminium absorption observed earlier in healthy subjects and in non-renal patients with duodenal ulcer. To ward off complications, a strong warning is given against administration of any aluminium-containing medicament or food to subjects with reduced renal function.",
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