Kinetic study of zinc sulphate release from lipophilic matrices prepared for the therapy of Wilson's disease

J. Nagy, A. Folhoffer, A. Horvath, T. Csak, G. Taba, K. Szentmihályi, F. Szalay, R. Zelkó

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The rate and extent of drug release from the most controlled release wax matrices are influenced by the drug loading/embedding excipient ratio of the systems. In the present study hydrophobic wax - zinc sulphate matrices with different drug loadings were prepared for the therapy of Wilson's disease. The drug release was tested by the paddle method of USP and the dissolution data were analysed. Both the dissolution rate and kinetic profile can be controlled by alteration in the quantity of embedding material. Matrices of 75% zinc sulphate loadings showed steady state diffusion-controlled matrix release with good correlation in vitro. Good absorption of zinc sulphate from the gastrointestinal tract was proven by significant elevation of serum zinc level in patients with Wilson's disease.

Original languageEnglish
Pages (from-to)524-526
Number of pages3
JournalPharmazie
Volume60
Issue number7
Publication statusPublished - Jul 2005

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Zinc Sulfate
Hepatolenticular Degeneration
Waxes
Kinetics
Pharmaceutical Preparations
Dissolution
Excipients
Gastrointestinal Tract
Zinc
Therapeutics
Serum
Drug Liberation

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Kinetic study of zinc sulphate release from lipophilic matrices prepared for the therapy of Wilson's disease. / Nagy, J.; Folhoffer, A.; Horvath, A.; Csak, T.; Taba, G.; Szentmihályi, K.; Szalay, F.; Zelkó, R.

In: Pharmazie, Vol. 60, No. 7, 07.2005, p. 524-526.

Research output: Contribution to journalArticle

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