Kinetic studies in isolated organs: Tools to design analgesic peptides and to analyze their receptor effects

A. Z. Ronai, I. Berzetei, J. I. Szekely, L. Gráf, S. Bajusz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The opioid activities of peptide and non-peptide narcotics were studied in longitudinal muscle strip of guinea pig ileum (GPI) and in mouse vas deferens (MVD). The comparison of agonist activities of peptides found in GPI and MVD offered the opportunity to predict the presence but not the magnitude of potential analgesic activity. The kinetics of the antagonism between naltrexone and different types of agonists were also determined in these systems. Using C-6 epimers of naltrexone, it was found that the site of opiate receptors recognizing the information provided by the C-6 substituent of naltrexone are different in GPI and MVD.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalUnknown Journal
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 1 1979

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology

Cite this