Kinetic resolution of a series of racemic trans-cycloalkane-1,2-diol monoacetates rac-2a-d was performed by enantiomerically selective transesterification with vinyl acetate catalysed by commercial and our own-prepared fungal lipases to yield diacetates (R,R)-3a-d and monoacetates (S,S)-2a-d in high enantiomeric purity. The monoacetates (R,R)-2a-d were also prepared from the racemic diacetates rac-3a-d by lipase-catalysed hydrolysis.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
- Inorganic Chemistry