Kinetic resolution of trans-2-acetoxycycloalkan-1-ols by lipase-catalysed enantiomerically selective acylation

Viktória Bódai, Olivér Orovecz, György Szakács, Lajos Novák, László Poppe

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Kinetic resolution of a series of racemic trans-cycloalkane-1,2-diol monoacetates rac-2a-d was performed by enantiomerically selective transesterification with vinyl acetate catalysed by commercial and our own-prepared fungal lipases to yield diacetates (R,R)-3a-d and monoacetates (S,S)-2a-d in high enantiomeric purity. The monoacetates (R,R)-2a-d were also prepared from the racemic diacetates rac-3a-d by lipase-catalysed hydrolysis.

Original languageEnglish
Pages (from-to)2605-2612
Number of pages8
JournalTetrahedron Asymmetry
Volume14
Issue number17
DOIs
Publication statusPublished - Sep 5 2003

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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