Kinetic metabolism of vinpocetine in the rat

L. Vereczkey, Zs Szentirmay, L. Szporny

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The pharmacokinetics of vinpocetine (Cavinton), a new potent vasodilator, and of its main metabolite have been studied in rats by specific extraction and radio thin-layer chromatography following i.v. and p.o. administration. The drug is rapidly eliminated, its half-life was found to be 125 min. The apparent volume of distribution was 3.8 l/kg and the clearance rate 33 ml/min/kg. From the equation describing the concentration-time curve a two-compartment open model was computed. Bioavailability of vinpocetine after p.o. administration was about 50%. The main metabolite, free apovincaminic acid, is formed very rapidly in rats and is eliminated from plasma with a half-life of 360 min.

Original languageEnglish
Pages (from-to)953-956
Number of pages4
JournalArzneimittel-Forschung
Volume29
Issue number6
Publication statusPublished - 1979

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vinpocetine
Enzyme kinetics
Metabolism
Rats
Metabolites
Half-Life
Thin layer chromatography
Pharmacokinetics
Thin Layer Chromatography
Radio
Vasodilator Agents
Biological Availability
Plasmas
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Vereczkey, L., Szentirmay, Z., & Szporny, L. (1979). Kinetic metabolism of vinpocetine in the rat. Arzneimittel-Forschung, 29(6), 953-956.

Kinetic metabolism of vinpocetine in the rat. / Vereczkey, L.; Szentirmay, Zs; Szporny, L.

In: Arzneimittel-Forschung, Vol. 29, No. 6, 1979, p. 953-956.

Research output: Contribution to journalArticle

Vereczkey, L, Szentirmay, Z & Szporny, L 1979, 'Kinetic metabolism of vinpocetine in the rat', Arzneimittel-Forschung, vol. 29, no. 6, pp. 953-956.
Vereczkey, L. ; Szentirmay, Zs ; Szporny, L. / Kinetic metabolism of vinpocetine in the rat. In: Arzneimittel-Forschung. 1979 ; Vol. 29, No. 6. pp. 953-956.
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