Kinetic and theoretic aspects of regiochemistry in the reaction of 4,5-dihalo-3(2H)-pyridazinones with benzylamines

P. Mátyus, Klára Czakó, Ágnes Behr, Ildikó Varga, Benjamin Podányi, Malte von Arnim, Péter Várkonyi

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12 Citations (Scopus)

Abstract

Regioselectivity of nucleophilic substitution reactions of 4,5-dihalo-3(2H)-pyridazinones (1a-d) with benzylamines was studied under different conditions. Second-order kinetics were obtained for reactions of 1a with benzylamine in ethanol-d6 and toluene-d8 as well. Experimental results obtained were interpreted on the bases of Klopman-Salem equation and analyses of the reaction paths.

Original languageEnglish
Pages (from-to)785-798
Number of pages14
JournalHeterocycles
Volume36
Issue number4
Publication statusPublished - Apr 1 1993

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Benzylamines
Regioselectivity
Toluene
Substitution reactions
Ethanol
Kinetics
benzylamine

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Mátyus, P., Czakó, K., Behr, Á., Varga, I., Podányi, B., von Arnim, M., & Várkonyi, P. (1993). Kinetic and theoretic aspects of regiochemistry in the reaction of 4,5-dihalo-3(2H)-pyridazinones with benzylamines. Heterocycles, 36(4), 785-798.

Kinetic and theoretic aspects of regiochemistry in the reaction of 4,5-dihalo-3(2H)-pyridazinones with benzylamines. / Mátyus, P.; Czakó, Klára; Behr, Ágnes; Varga, Ildikó; Podányi, Benjamin; von Arnim, Malte; Várkonyi, Péter.

In: Heterocycles, Vol. 36, No. 4, 01.04.1993, p. 785-798.

Research output: Contribution to journalArticle

Mátyus, P, Czakó, K, Behr, Á, Varga, I, Podányi, B, von Arnim, M & Várkonyi, P 1993, 'Kinetic and theoretic aspects of regiochemistry in the reaction of 4,5-dihalo-3(2H)-pyridazinones with benzylamines', Heterocycles, vol. 36, no. 4, pp. 785-798.
Mátyus, P. ; Czakó, Klára ; Behr, Ágnes ; Varga, Ildikó ; Podányi, Benjamin ; von Arnim, Malte ; Várkonyi, Péter. / Kinetic and theoretic aspects of regiochemistry in the reaction of 4,5-dihalo-3(2H)-pyridazinones with benzylamines. In: Heterocycles. 1993 ; Vol. 36, No. 4. pp. 785-798.
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