Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil

A case report

G. Telkes, A. Pusztai, K. Földes, R. Langer

Research output: Contribution to journalArticle

Abstract

Background The porphyrias are a group of disorders of the heme biosynthesis pathway that may present with acute life-threatening attacks, commonly exacerbated by a wide variety of medications. Many newer immunosuppressive medications, which are in use following kidney transplantation, have not been fully explored in acute porphyrias. Case report A 53-year-old woman received a kidney from a deceased donor, after being on hemodialysis for 4 years. Hereditary coproporphyria was diagnosed at age 19 years. We administered tacrolimus, mycophenolate mofetil and steroid immunosuppression. In the immediate post-transplant periods she displayed abdominal pain and transient uroporphyrin elevation in parallel with slightly elevated (15 ng/mL) tacrolimus concentrations. As the target tacrolimus level was achieved, these findings disappeared. Conclusions Tacrolimus, mycophenolate- mofetil, and steroid therapy for hereditery coproporphyri was safe, in the long term.

Original languageEnglish
Pages (from-to)3703-3704
Number of pages2
JournalTransplantation Proceedings
Volume45
Issue number10
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Hereditary Coproporphyria
Mycophenolic Acid
Tacrolimus
Kidney Transplantation
Uroporphyrins
Steroids
Acute Intermittent Porphyria
Porphyrias
Immunosuppressive Agents
Heme
Immunosuppression
Abdominal Pain
Renal Dialysis
Tissue Donors
Transplants
Kidney

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Kidney transplantation in hereditary coproporphyria using tacrolimus and mycophenolate mofetil : A case report. / Telkes, G.; Pusztai, A.; Földes, K.; Langer, R.

In: Transplantation Proceedings, Vol. 45, No. 10, 12.2013, p. 3703-3704.

Research output: Contribution to journalArticle

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