Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: A multicenter study

B. Ghanim, T. Klikovits, M. A. Hoda, G. Lang, I. Szirtes, U. Setinek, A. Rozsas, F. Renyi-Vamos, V. Laszlo, M. Grusch, M. Filipits, A. Scheed, M. Jakopovic, M. Samarzija, L. Brcic, D. Stancic-Rokotov, I. Kern, A. Rozman, G. Dekan, W. KlepetkoW. Berger, T. Glasz, B. Dome, B. Hegedus

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Estimating the prognosis in malignant pleural mesothelioma (MPM) remains challenging. Thus, the prognostic relevance of Ki67 was studied in MPM.Methods:Ki67 index was determined in a test cohort of 187 cases from three centres. The percentage of Ki67-positive tumour cells was correlated with clinical variables and overall survival (OS). The prognostic power of Ki67 index was compared with other prognostic factors and re-evaluated in an independent cohort (n=98).Results:Patients with Ki67 higher than median (>15%) had significantly (P<0.001) shorter median OS (7.5 months) than those with low Ki67 (19.1 months). After multivariate survival analyses, Ki67 proved to be-beside histology and treatment-an independent prognostic marker in MPM (hazard ratio (HR): 2.1, P<0.001). Interestingly, Ki67 was prognostic exclusively in epithelioid (P<0.001) but not in non-epithelioid subtype. Furthermore, Ki67 index was significantly lower in post-chemotherapy samples when compared with chemo-naive cases. The prognostic power was comparable to other recently published prognostic factors (CRP, fibrinogen, neutrophil-to-leukocyte ratio (NLR) and nuclear grading score) and was recapitulated in the validation cohort (P=0.048).Conclusion:This multicentre study demonstrates that Ki67 is an independent and reproducible prognostic factor in epithelioid but not in non-epithelioid MPM and suggests that induction chemotherapy decreases the proliferative capacity of MPM.

Original languageEnglish
Pages (from-to)783-792
Number of pages10
JournalBritish journal of cancer
Volume112
Issue number5
DOIs
Publication statusPublished - Mar 3 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: A multicenter study'. Together they form a unique fingerprint.

  • Cite this

    Ghanim, B., Klikovits, T., Hoda, M. A., Lang, G., Szirtes, I., Setinek, U., Rozsas, A., Renyi-Vamos, F., Laszlo, V., Grusch, M., Filipits, M., Scheed, A., Jakopovic, M., Samarzija, M., Brcic, L., Stancic-Rokotov, D., Kern, I., Rozman, A., Dekan, G., ... Hegedus, B. (2015). Ki67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: A multicenter study. British journal of cancer, 112(5), 783-792. https://doi.org/10.1038/bjc.2015.9