Ketoconazole in vitro inhibits mitogen-induced blastogenesis, antibody-dependent cellular cytotoxicity, natural killer activity and random migration of human leukocytes

Péter Gergely, Kristóf Nékam, István Láng, László Kalmár, Rhenso González-Cabello, András Perl

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ketoconazole at concentrations of 1-10 μg/ml dose dependently inhibits mitogen-induced blastogenesis, antibody-dependent and spontaneous cytotoxic (natural killer) activity of human lymphocytes and random migration of human leukocytes. Lectin-dependent cytotoxic activity is not affected by the drug.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalImmunopharmacology
Volume7
Issue number3-4
DOIs
Publication statusPublished - Jun 1984

Keywords

  • Antibody-dependent cytotoxicity
  • Immunosuppression
  • Ketoconazole
  • Lectin-dependent cell-mediated cytotoxicity
  • Leukocyte random migration
  • PHA-induced blastogenesis
  • Spontaneous (NK) cytotoxicity

ASJC Scopus subject areas

  • Pharmacology

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