Ketoconazole at concentrations of 1-10 μg/ml dose dependently inhibits mitogen-induced blastogenesis, antibody-dependent and spontaneous cytotoxic (natural killer) activity of human lymphocytes and random migration of human leukocytes. Lectin-dependent cytotoxic activity is not affected by the drug.
- Antibody-dependent cytotoxicity
- Lectin-dependent cell-mediated cytotoxicity
- Leukocyte random migration
- PHA-induced blastogenesis
- Spontaneous (NK) cytotoxicity
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