Keratinocyte grafting: A new means of transplantation for full-thickness wounds

J. Hunyadi, B. Farkas, C. Bertenyi, J. Oláh, A. Dobozy

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Twenty adult individuals with chronic leg ulcers caused by venous insufficiency, and 5 patients with full-thickness burns were treated. Twenty of the patients (15 with leg ulcers and 5 with burns) were grafted with separated autologous keratinocytes. In these cases the cells were fixed to the wound bed by a fibrin net. Five other patients (with leg ulcers) were treated with fibrin without keratinocytes. In 16 of the 20 patients grafted with keratinocytes in a fibrin net, the defect healed completely in 14 to 21 days. On the other hand, the fibrin net without keratinocytes failed to significantly accelerate the process of reepithelialization. Our experience suggests that a rapid healing of full-thickness skin defects can be achieved through keratinocyte grafting.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalJournal of Dermatologic Surgery and Oncology
Volume14
Issue number1
Publication statusPublished - 1988

Fingerprint

Keratinocytes
Fibrin
Transplantation
Leg Ulcer
Wounds and Injuries
Burns
Venous Insufficiency
Skin

ASJC Scopus subject areas

  • Dermatology
  • Oncology

Cite this

Keratinocyte grafting : A new means of transplantation for full-thickness wounds. / Hunyadi, J.; Farkas, B.; Bertenyi, C.; Oláh, J.; Dobozy, A.

In: Journal of Dermatologic Surgery and Oncology, Vol. 14, No. 1, 1988, p. 75-78.

Research output: Contribution to journalArticle

@article{2c3be883c1a84808916d8a7daa498d2c,
title = "Keratinocyte grafting: A new means of transplantation for full-thickness wounds",
abstract = "Twenty adult individuals with chronic leg ulcers caused by venous insufficiency, and 5 patients with full-thickness burns were treated. Twenty of the patients (15 with leg ulcers and 5 with burns) were grafted with separated autologous keratinocytes. In these cases the cells were fixed to the wound bed by a fibrin net. Five other patients (with leg ulcers) were treated with fibrin without keratinocytes. In 16 of the 20 patients grafted with keratinocytes in a fibrin net, the defect healed completely in 14 to 21 days. On the other hand, the fibrin net without keratinocytes failed to significantly accelerate the process of reepithelialization. Our experience suggests that a rapid healing of full-thickness skin defects can be achieved through keratinocyte grafting.",
author = "J. Hunyadi and B. Farkas and C. Bertenyi and J. Ol{\'a}h and A. Dobozy",
year = "1988",
language = "English",
volume = "14",
pages = "75--78",
journal = "Dermatologic Surgery",
issn = "1076-0512",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Keratinocyte grafting

T2 - A new means of transplantation for full-thickness wounds

AU - Hunyadi, J.

AU - Farkas, B.

AU - Bertenyi, C.

AU - Oláh, J.

AU - Dobozy, A.

PY - 1988

Y1 - 1988

N2 - Twenty adult individuals with chronic leg ulcers caused by venous insufficiency, and 5 patients with full-thickness burns were treated. Twenty of the patients (15 with leg ulcers and 5 with burns) were grafted with separated autologous keratinocytes. In these cases the cells were fixed to the wound bed by a fibrin net. Five other patients (with leg ulcers) were treated with fibrin without keratinocytes. In 16 of the 20 patients grafted with keratinocytes in a fibrin net, the defect healed completely in 14 to 21 days. On the other hand, the fibrin net without keratinocytes failed to significantly accelerate the process of reepithelialization. Our experience suggests that a rapid healing of full-thickness skin defects can be achieved through keratinocyte grafting.

AB - Twenty adult individuals with chronic leg ulcers caused by venous insufficiency, and 5 patients with full-thickness burns were treated. Twenty of the patients (15 with leg ulcers and 5 with burns) were grafted with separated autologous keratinocytes. In these cases the cells were fixed to the wound bed by a fibrin net. Five other patients (with leg ulcers) were treated with fibrin without keratinocytes. In 16 of the 20 patients grafted with keratinocytes in a fibrin net, the defect healed completely in 14 to 21 days. On the other hand, the fibrin net without keratinocytes failed to significantly accelerate the process of reepithelialization. Our experience suggests that a rapid healing of full-thickness skin defects can be achieved through keratinocyte grafting.

UR - http://www.scopus.com/inward/record.url?scp=0023911078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023911078&partnerID=8YFLogxK

M3 - Article

C2 - 2447135

AN - SCOPUS:0023911078

VL - 14

SP - 75

EP - 78

JO - Dermatologic Surgery

JF - Dermatologic Surgery

SN - 1076-0512

IS - 1

ER -