Karyotyping from uncultured human trophoblast in the first trimester of pregnancy

János Szabó, János Herczeg, László Thurzó, György Szemere

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12 Citations (Scopus)


Chorionic villi were sampled by transcervical aspiration after ultrasonic localization of the chorion frondosum. Sampling was successful in 82 of 98 women. Subsequent karyo-typing of the chorionic material was done by the modified Evans method. Mitoses of reasonable quality were obtained providing an easy cytogenetic diagnosis from human cytotrophoblast. A second trimester chorionic plate biopsy and direct karyotyping in case of severe oligohydramnios and malformed fetus revealing numerical (45, XO) chromosomal abnormality is also reported.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalObstetrics and Gynecology
Issue number6
Publication statusPublished - Dec 1984

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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