Karyotyping from uncultured human trophoblast in the first trimester of pregnancy

János Szabó, János Herczeg, László Thurzó, György Szemere

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Chorionic villi were sampled by transcervical aspiration after ultrasonic localization of the chorion frondosum. Sampling was successful in 82 of 98 women. Subsequent karyo-typing of the chorionic material was done by the modified Evans method. Mitoses of reasonable quality were obtained providing an easy cytogenetic diagnosis from human cytotrophoblast. A second trimester chorionic plate biopsy and direct karyotyping in case of severe oligohydramnios and malformed fetus revealing numerical (45, XO) chromosomal abnormality is also reported.

Original languageEnglish
Pages (from-to)807-810
Number of pages4
JournalObstetrics and Gynecology
Volume64
Issue number6
Publication statusPublished - Dec 1984

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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