Objectives: We analyzed the manifestation and clinical course of Kaposi's sarcoma cases in Kidney transplant recipients. Material and methods: We performed 850 kidney transplantations from 1973 to 1993. During the follow-up of patients 30 malignant tumours were detected, they occurred in 28 patients. The mean age of the patients was 34-5 years. The average follow-up time was 5.6 years. Results: We found a higher tumour incidence (3.5 %) in patients receiving immunosuppressive therapy. According to the literature skin cancer was the most frequently found tumour (10/30). Two of them had cutaneous and 2 visceral manifestation. All our cases were HIV, EBV, hepatitis B surface antigen negative. One patient had serological proved CMV infection. All patients received Cyclosporin immunosuppressive therapy and all our Kaposi's sarcoma patients were male. Conclusions: Kaposi's sarcoma in the immunosuppression is a new presentation of a previously rare malignancy. There is a great difference in the clinical course of the cutaneous and visceral manifestations. The skin lesion on the lower extremities, the "classical form" developed more slowly (13 months), and they responded well to irradiation. The visceral form of Kaposi's sarcoma developed very rapidly after transplantation (4-5 months). This aggressive form carries a poor prognosis. Recovery of Kaposi's sarcoma can be associated in kidney transplantation either with reduced immunosuppressive therapy alone or with antitumoral radio/chemotherapy.
|Translated title of the contribution||Kaposi's sarcoma in immunosuppression|
|Number of pages||4|
|Publication status||Published - Dec 1 1996|
ASJC Scopus subject areas