Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8: A new virus in human pathology

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Abstract

The discovery of a new human herpesvirus in Kaposi's sarcoma (KS) tissue of patients with AIDS has opened up new vistas in virology and oncology. This herpesvirus was first descriptively named KS-associated herpesvirus (KSHV), but was recently renamed human herpesvirus 8 (HHV8). KSHV/HHV8 DNA has been found in all forms of KS, suggesting that it might be involved in the pathogenesis of KS. In addition, KSHV/HHV8 can be detected in both malignant and benign lymphoproliferative diseases, such as body cavity-based B-cell lymphomas and multicentric Castleman's disease. KSHV/HHV8 was also found in patients with angiosarcoma of the face and angiolymphoid hyperplasia with eosinophilia. Although only a limited portion of the virus has been sequenced, KSHV/HHV8 is equipped with genes that could confer oncogenic potential. The virus can now be cultured, providing the possibility for studies of vital replication and the mode of transmission. The recently developed serologic assays for antiviral antibodies suggest that infection with KSHV/HHV8 is not ubiquitous because KSHV/HHV8 seropositivity is limited to a small proportion of the population.

Original languageEnglish
Pages (from-to)107-103
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume37
Issue number1
DOIs
Publication statusPublished - 1997

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Human Herpesvirus 8
Herpesviridae
Pathology
Viruses
Kaposi's Sarcoma
Angiolymphoid Hyperplasia with Eosinophilia
Hemangiosarcoma
Virology
B-Cell Lymphoma
Antiviral Agents
Acquired Immunodeficiency Syndrome
Antibodies
DNA

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8: A new virus in human pathology",
abstract = "The discovery of a new human herpesvirus in Kaposi's sarcoma (KS) tissue of patients with AIDS has opened up new vistas in virology and oncology. This herpesvirus was first descriptively named KS-associated herpesvirus (KSHV), but was recently renamed human herpesvirus 8 (HHV8). KSHV/HHV8 DNA has been found in all forms of KS, suggesting that it might be involved in the pathogenesis of KS. In addition, KSHV/HHV8 can be detected in both malignant and benign lymphoproliferative diseases, such as body cavity-based B-cell lymphomas and multicentric Castleman's disease. KSHV/HHV8 was also found in patients with angiosarcoma of the face and angiolymphoid hyperplasia with eosinophilia. Although only a limited portion of the virus has been sequenced, KSHV/HHV8 is equipped with genes that could confer oncogenic potential. The virus can now be cultured, providing the possibility for studies of vital replication and the mode of transmission. The recently developed serologic assays for antiviral antibodies suggest that infection with KSHV/HHV8 is not ubiquitous because KSHV/HHV8 seropositivity is limited to a small proportion of the population.",
author = "L. Kem{\'e}ny and R. Gyulai and M. Kiss and F. Nagy and A. Dobozy",
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AU - Kemény, L.

AU - Gyulai, R.

AU - Kiss, M.

AU - Nagy, F.

AU - Dobozy, A.

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AB - The discovery of a new human herpesvirus in Kaposi's sarcoma (KS) tissue of patients with AIDS has opened up new vistas in virology and oncology. This herpesvirus was first descriptively named KS-associated herpesvirus (KSHV), but was recently renamed human herpesvirus 8 (HHV8). KSHV/HHV8 DNA has been found in all forms of KS, suggesting that it might be involved in the pathogenesis of KS. In addition, KSHV/HHV8 can be detected in both malignant and benign lymphoproliferative diseases, such as body cavity-based B-cell lymphomas and multicentric Castleman's disease. KSHV/HHV8 was also found in patients with angiosarcoma of the face and angiolymphoid hyperplasia with eosinophilia. Although only a limited portion of the virus has been sequenced, KSHV/HHV8 is equipped with genes that could confer oncogenic potential. The virus can now be cultured, providing the possibility for studies of vital replication and the mode of transmission. The recently developed serologic assays for antiviral antibodies suggest that infection with KSHV/HHV8 is not ubiquitous because KSHV/HHV8 seropositivity is limited to a small proportion of the population.

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