Kaposi-sarcomához asszociált herpesvirus: human herpesvirus 8.

Translated title of the contribution: Kaposi sarcoma-associated herpesvirus; human herpesvirus 8

Research output: Contribution to journalArticle

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Abstract

The discovery of a new human herpesvirus in Kaposi's sarcoma tissues of AIDS patients has opened up new facts in virology and oncology. This herpesvirus was first descriptively named Kaposi's sarcoma-associated herpesvirus, but was recently renamed human herpesvirus 8. Human herpesvirus 8 DNA has been consequently found in all forms of Kaposi's sarcoma, suggesting that it might be involved in the pathogenesis of the disease. Additionally, human herpesvirus 8 can be detected in both malignant and benign lymphoproliferative diseases, such as body-cavity-based B-cell lymphomas and multicentric Castleman disease. The virus was also recently found in rare vascular tumors in patients with angiosarcoma of the face and angiolymphoid hyperplasia with eosinophilia. Although only a limited portion of the viral DNA has been sequenced, it has become evident that the new herpesvirus is equipped with genes that could confer oncogenic potential. The virus can now be cultured, providing the possibility for studies of viral replication and the mode of transmission, and also for the development of serologic tests.

Original languageHungarian
Pages (from-to)979-983
Number of pages5
JournalOrvosi Hetilap
Volume138
Issue number16
Publication statusPublished - Apr 20 1997

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Human Herpesvirus 8
Herpesviridae
Kaposi's Sarcoma
Angiolymphoid Hyperplasia with Eosinophilia
Viruses
Hemangiosarcoma
Virology
Viral DNA
Serologic Tests
B-Cell Lymphoma
Blood Vessels
Acquired Immunodeficiency Syndrome
DNA
Genes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kaposi-sarcomához asszociált herpesvirus : human herpesvirus 8. / Kemény, L.; Gyulani, R.; Kiss, M.; Dobozy, A.

In: Orvosi Hetilap, Vol. 138, No. 16, 20.04.1997, p. 979-983.

Research output: Contribution to journalArticle

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