Kainic acid neurotoxicity: Characterization of blood-brain barrier damage

L. Sztriha, Ferenc Joó, Péter Szerdahelyi, Zoltán Lelkes, Géza Ádám

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The alterations in the water, sodium (Na) and potassium (K) contents of the frontoparietal cortex, hippocampus and thalamus as well as the protein permeability of the blood-brain barrier were investigated in rats 4 h after systemic kainic acid administration. Increases in the water and Na contents and a decrease in the K content were observed together with Evans blue extravasation in the thalamus area indicating the development of vasogenic brain edema. Changes observed in the ion contents of the frontoparietal cortex and hippocampus may be due to a general cell membrane permeability damage but are not caused by a primary disturbance of the blood-brain barrier.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalNeuroscience Letters
Volume55
Issue number2
DOIs
Publication statusPublished - Apr 9 1985

Fingerprint

Kainic Acid
Blood-Brain Barrier
Thalamus
Hippocampus
Cell Membrane Permeability
Evans Blue
Water
Brain Edema
Permeability
Potassium
Sodium
Ions
Proteins

Keywords

  • blood-brain barrier
  • kainic acid
  • rat
  • sodium, potassium contents
  • thalamus
  • water content

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kainic acid neurotoxicity : Characterization of blood-brain barrier damage. / Sztriha, L.; Joó, Ferenc; Szerdahelyi, Péter; Lelkes, Zoltán; Ádám, Géza.

In: Neuroscience Letters, Vol. 55, No. 2, 09.04.1985, p. 233-237.

Research output: Contribution to journalArticle

Sztriha, L. ; Joó, Ferenc ; Szerdahelyi, Péter ; Lelkes, Zoltán ; Ádám, Géza. / Kainic acid neurotoxicity : Characterization of blood-brain barrier damage. In: Neuroscience Letters. 1985 ; Vol. 55, No. 2. pp. 233-237.
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