Kainate-induced inhibition of voltage-activated potassium currents in cultured chick telencephalic neurons

A. Mike, V. Dyatlov, E. Vízi

Research output: Contribution to journalArticle

Abstract

Kainate indirectly produces an inhibition of voltage-activated outward potassium currents on cultured chick telencephalic neurons, besides directly evoking activation of AMPA/kainate receptors (current with linear I-V curve, reversal potential near 0 mV). The former effect is also mediated by AMPA/kainate receptors. The role of [Ca2+]i in the inhibition was investigated by whole cell- and nystatin-perforated patch-clamp technique. Elevation of [Ca2+]i evoked by the Ca2+ ionophores ionomycin and A23187 caused an inhibition of outward currents as well. When the elevation of [Ca2+]i is prevented, the inhibition is decreased. These results suggest that [Ca2+]i elevation may be involved in the process.

Original languageEnglish
Pages (from-to)311-312
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Fingerprint

Kainic Acid Receptors
Telencephalon
AMPA Receptors
Kainic Acid
Potassium
Neurons
Nystatin
Ionomycin
Ionophores
Calcimycin
Patch-Clamp Techniques

Keywords

  • Chick
  • Glutamate receptors
  • Intracellular Ca
  • Potassium currents

ASJC Scopus subject areas

  • Physiology

Cite this

Kainate-induced inhibition of voltage-activated potassium currents in cultured chick telencephalic neurons. / Mike, A.; Dyatlov, V.; Vízi, E.

In: Acta Physiologica Hungarica, Vol. 84, No. 3, 1996, p. 311-312.

Research output: Contribution to journalArticle

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