Mutazioni K-ras nei tessuti tumorali e nei campioni di sangue periferico in pazienti ungheresi affetti da adenocarcinoma pancreatico

Translated title of the contribution: K-ras mutations in tumour specimens and peripheral blood samples of Hungarian patients with pancreatic adenocarcinoma

Edit Nádasi, Tímea Varjas, Ida Prantner, Róbert Papp, Ghodratollah Nowrasteh, I. Ember, Dezso Kelemen

Research output: Contribution to journalArticle

Abstract

Aim: Pancreatic cancer is a deadly disease, with a mortality rate approximately equal to the incidence rate. One prominent feature of the disease is the high frequency of K-ras mutations, associated with certain risk factors. Since patients are usually observed at an advanced stage, a less invasive screening test, allowing for early diagnosis, would be of great utility. Patients and Methods: Tumour and blood samples of 28 patients with histologically verified pancreatic adenocarcinoma were screened for K-ras mutations and K-ras gene expression. Known risk factors of pancreatic cancer were investigated by a questionnaire. Results: Significant relationships were found between polluted environment and Kras gene mutations, alcohol consumption and codon 61 mutations and coffee consumption and codon 12 mutations. Of interest, meat consumption showed a protective effect against codon 61 mutations. Though K-ras status of the tumour and blood samples were the same in 71.4% of the cases, no significant relationship between the presence of the K-ras mutations and the gene expression were found either in the tumour or the blood samples. Conclusions: Our results indicate that K-ras mutations are often found in blood samples of patients with pancreatic adenocarcinoma. Due to the small number of patients of the present investigations, further studies are required to assess the relevance of our findings for the clinical practice.

Original languageItalian
Pages (from-to)129-138
Number of pages10
JournalEuropean Journal of Oncology
Volume16
Issue number3
Publication statusPublished - Sep 2011

Fingerprint

Adenocarcinoma
Mutation
Neoplasms
Codon
ras Genes
Pancreatic Neoplasms
Gene Expression
Coffee
Alcohol Drinking
Meat
Early Diagnosis
Mortality
Incidence
Genes

Keywords

  • Blood sample
  • Gene expression
  • Kras mutation
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology

Cite this

Mutazioni K-ras nei tessuti tumorali e nei campioni di sangue periferico in pazienti ungheresi affetti da adenocarcinoma pancreatico. / Nádasi, Edit; Varjas, Tímea; Prantner, Ida; Papp, Róbert; Nowrasteh, Ghodratollah; Ember, I.; Kelemen, Dezso.

In: European Journal of Oncology, Vol. 16, No. 3, 09.2011, p. 129-138.

Research output: Contribution to journalArticle

Nádasi, Edit ; Varjas, Tímea ; Prantner, Ida ; Papp, Róbert ; Nowrasteh, Ghodratollah ; Ember, I. ; Kelemen, Dezso. / Mutazioni K-ras nei tessuti tumorali e nei campioni di sangue periferico in pazienti ungheresi affetti da adenocarcinoma pancreatico. In: European Journal of Oncology. 2011 ; Vol. 16, No. 3. pp. 129-138.
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abstract = "Aim: Pancreatic cancer is a deadly disease, with a mortality rate approximately equal to the incidence rate. One prominent feature of the disease is the high frequency of K-ras mutations, associated with certain risk factors. Since patients are usually observed at an advanced stage, a less invasive screening test, allowing for early diagnosis, would be of great utility. Patients and Methods: Tumour and blood samples of 28 patients with histologically verified pancreatic adenocarcinoma were screened for K-ras mutations and K-ras gene expression. Known risk factors of pancreatic cancer were investigated by a questionnaire. Results: Significant relationships were found between polluted environment and Kras gene mutations, alcohol consumption and codon 61 mutations and coffee consumption and codon 12 mutations. Of interest, meat consumption showed a protective effect against codon 61 mutations. Though K-ras status of the tumour and blood samples were the same in 71.4{\%} of the cases, no significant relationship between the presence of the K-ras mutations and the gene expression were found either in the tumour or the blood samples. Conclusions: Our results indicate that K-ras mutations are often found in blood samples of patients with pancreatic adenocarcinoma. Due to the small number of patients of the present investigations, further studies are required to assess the relevance of our findings for the clinical practice.",
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AU - Nowrasteh, Ghodratollah

AU - Ember, I.

AU - Kelemen, Dezso

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