Junctional region of the myelin basic protein-specific T cell receptor β chain in mice

B. Kálmán, Hansjuerg Alder, Robert L. Knobler

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Evidence for the existence of both conserved and diverse amino acid sequences in the Junctional regions of the myelin basic protein (MBP)-specific T cell receptors (TCR) in mice is presented. The Junctional region of the Nacl-11 MBP peptide-specific, H-2u-restricted TCR β-chains is characterized by the utilization of similar amino acid sequences. In contrast, diverse Junctional sequences within the TCR β-chains of the p89-101 MBP peptide and H-2s-restricted T cell clones are reported. These findings demonstrate that a limited heterogeneity of the MBP-specific T cell clones does exist. However, it may not be universal even in inbred mouse strains.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalJournal of Neuroimmunology
Volume59
Issue number1-2
DOIs
Publication statusPublished - 1995

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Myelin Basic Protein
T-Cell Antigen Receptor
Amino Acid Sequence
Clone Cells
T-Lymphocytes
Peptides
Inbred Strains Mice

Keywords

  • Junctional region
  • Limited heterogeneity
  • T cell receptor

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

Cite this

Junctional region of the myelin basic protein-specific T cell receptor β chain in mice. / Kálmán, B.; Alder, Hansjuerg; Knobler, Robert L.

In: Journal of Neuroimmunology, Vol. 59, No. 1-2, 1995, p. 195-199.

Research output: Contribution to journalArticle

Kálmán, B. ; Alder, Hansjuerg ; Knobler, Robert L. / Junctional region of the myelin basic protein-specific T cell receptor β chain in mice. In: Journal of Neuroimmunology. 1995 ; Vol. 59, No. 1-2. pp. 195-199.
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