Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia

Beata Bessenyei, Aniko Ujfalusi, Erzsebet Balogh, Eva Olah, Istvan Szegedi, Csongor Kiss

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Acquired jumping translocations (JTs) are rare secondary aberrations occurring in various hematological malignancies. In Burkitt lymphoma/leukemia (BL) chromosome 1q abnormalities such as partial or whole arm duplications/translocations are frequently associated with the disease-specific t(8;14)(q24;q32). JTs of 1q are considered to have a bad prognostic impact in BL. We report clinical, conventional and molecular cytogenetic findings of a 12-year-old boy who presented with BL. In addition to the primary aberration, t(8;14)(q24;q32), JT of 1q onto chromosomes 21 and der(14) as well as the formation of isochromosome 1q could be detected in his bone marrow sample. Despite the expected poor prognostic outcome of these aberrations, the patient has been experiencing an event free survival of 7.5 years at the time of the present report, reflecting the excellent clinical outcome of the disease.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalCancer Genetics
Volume204
Issue number4
DOIs
Publication statusPublished - Apr 1 2011

Keywords

  • 1q
  • Burkitt leukemia
  • Jumping translocation
  • MFISH

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia'. Together they form a unique fingerprint.

  • Cite this