Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia

Beata Bessenyei, Aniko Ujfalusi, Erzsebet Balogh, E. Oláh, Istvan Szegedi, C. Kiss

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acquired jumping translocations (JTs) are rare secondary aberrations occurring in various hematological malignancies. In Burkitt lymphoma/leukemia (BL) chromosome 1q abnormalities such as partial or whole arm duplications/translocations are frequently associated with the disease-specific t(8;14)(q24;q32). JTs of 1q are considered to have a bad prognostic impact in BL. We report clinical, conventional and molecular cytogenetic findings of a 12-year-old boy who presented with BL. In addition to the primary aberration, t(8;14)(q24;q32), JT of 1q onto chromosomes 21 and der(14) as well as the formation of isochromosome 1q could be detected in his bone marrow sample. Despite the expected poor prognostic outcome of these aberrations, the patient has been experiencing an event free survival of 7.5 years at the time of the present report, reflecting the excellent clinical outcome of the disease.

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalCancer genetics
Volume204
Issue number4
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Burkitt Lymphoma
Chromosomes
Isochromosomes
Chromosomes, Human, Pair 21
Hematologic Neoplasms
Cytogenetics
Chromosome Aberrations
Disease-Free Survival
Bone Marrow

Keywords

  • 1q
  • Burkitt leukemia
  • Jumping translocation
  • MFISH

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology
  • Medicine(all)

Cite this

Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia. / Bessenyei, Beata; Ujfalusi, Aniko; Balogh, Erzsebet; Oláh, E.; Szegedi, Istvan; Kiss, C.

In: Cancer genetics, Vol. 204, No. 4, 04.2011, p. 207-210.

Research output: Contribution to journalArticle

Bessenyei, Beata ; Ujfalusi, Aniko ; Balogh, Erzsebet ; Oláh, E. ; Szegedi, Istvan ; Kiss, C. / Jumping translocation of chromosome 1q associated with good clinical outcome in a case of Burkitt leukemia. In: Cancer genetics. 2011 ; Vol. 204, No. 4. pp. 207-210.
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