Journey of the iodide transporter NIS

From its molecular identification to its clinical role in cancer

Claudia Riedel, O. Dohán, Antonio De la Vieja, Christopher S. Ginter, Nancy Carrasco

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalTrends in Biochemical Sciences
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 1 2001

Fingerprint

Symporters
Iodides
Neoplasms
Thyroid Gland
Tissue
Active Biological Transport
Thyroid Diseases
Medical applications
Diagnostic Imaging
Cell membranes
Human Mammary Glands
Salivary Glands
Thyroid Neoplasms
Blood Proteins
Stomach
Membrane Proteins
Cell Membrane
Breast Neoplasms
Imaging techniques
Research

ASJC Scopus subject areas

  • Biochemistry

Cite this

Journey of the iodide transporter NIS : From its molecular identification to its clinical role in cancer. / Riedel, Claudia; Dohán, O.; De la Vieja, Antonio; Ginter, Christopher S.; Carrasco, Nancy.

In: Trends in Biochemical Sciences, Vol. 26, No. 8, 01.08.2001, p. 490-496.

Research output: Contribution to journalArticle

Riedel, Claudia ; Dohán, O. ; De la Vieja, Antonio ; Ginter, Christopher S. ; Carrasco, Nancy. / Journey of the iodide transporter NIS : From its molecular identification to its clinical role in cancer. In: Trends in Biochemical Sciences. 2001 ; Vol. 26, No. 8. pp. 490-496.
@article{ec4d8f6a21544168bcb280974a50c883,
title = "Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer",
abstract = "The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.",
author = "Claudia Riedel and O. Doh{\'a}n and {De la Vieja}, Antonio and Ginter, {Christopher S.} and Nancy Carrasco",
year = "2001",
month = "8",
day = "1",
doi = "10.1016/S0968-0004(01)01904-1",
language = "English",
volume = "26",
pages = "490--496",
journal = "Trends in Biochemical Sciences",
issn = "0968-0004",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Journey of the iodide transporter NIS

T2 - From its molecular identification to its clinical role in cancer

AU - Riedel, Claudia

AU - Dohán, O.

AU - De la Vieja, Antonio

AU - Ginter, Christopher S.

AU - Carrasco, Nancy

PY - 2001/8/1

Y1 - 2001/8/1

N2 - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

AB - The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

UR - http://www.scopus.com/inward/record.url?scp=0035425520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035425520&partnerID=8YFLogxK

U2 - 10.1016/S0968-0004(01)01904-1

DO - 10.1016/S0968-0004(01)01904-1

M3 - Article

VL - 26

SP - 490

EP - 496

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

IS - 8

ER -