Journey of the iodide transporter NIS: From its molecular identification to its clinical role in cancer

Claudia Riedel, Orsolya Dohán, Antonio De la Vieja, Christopher S. Ginter, Nancy Carrasco

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

Original languageEnglish
Pages (from-to)490-496
Number of pages7
JournalTrends in Biochemical Sciences
Volume26
Issue number8
DOIs
Publication statusPublished - Aug 1 2001

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ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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