Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring

Sára Antal, B. Szende, Jósef Lengyel, Egon J. Hidvégi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We have previously reported that irradiation of mice in utero significantly increased the tumor incidence in the offspring of irradiated mothers. The joint effects of irradiation and cigarette smoking (CS) on tumor incidence and on the process of carcinogenesis were investigated. Materials and Methods: Pregnant C57Bl/6J female mice were irradiated with a single dose of γ-ray (1Gy or 3Gy) and/or exposed to CS of lR3 non-filtered cigarettes before or during pregnancy, Tumors were investigated both with histological and immunohistochemical methods. Results: Longer exposure (60 days) of the mice to CS before pregnancy and irradiation during pregnancy significantly increased the tumor incidence in the mothers and their offspring. Parallel activation of Caspase-8 and inactivation of Caspase-9 was found. Conclusion: Joint exposure of mice to prolonged CS before pregnancy and irradiation during pregnancy significantly increased the tumor incidence both in the mothers and their offspring.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalIn Vivo
Volume23
Issue number2
Publication statusPublished - Mar 2009

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Tobacco Products
Tumors
Smoking
Irradiation
Pregnancy
Incidence
Neoplasms
Caspase 9
Caspase 8
Carcinogenesis
Joints
Chemical activation

Keywords

  • Apoptosis
  • Cigarette smoking
  • Irradiation
  • Tumor incidence
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring. / Antal, Sára; Szende, B.; Lengyel, Jósef; Hidvégi, Egon J.

In: In Vivo, Vol. 23, No. 2, 03.2009, p. 267-272.

Research output: Contribution to journalArticle

Antal, S, Szende, B, Lengyel, J & Hidvégi, EJ 2009, 'Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring', In Vivo, vol. 23, no. 2, pp. 267-272.
Antal, Sára ; Szende, B. ; Lengyel, Jósef ; Hidvégi, Egon J. / Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring. In: In Vivo. 2009 ; Vol. 23, No. 2. pp. 267-272.
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