Jatrophane diterpenes from euphorbia esula as antiproliferative agents and potent chemosensitizers to overcome multidrug resistance

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35 Citations (Scopus)

Abstract

Phytochemical study of whole, undried plants of Euphorbia esula led to the isolation of six new (1 - 6) jatrophane diterpene polyesters, named esulatins H - M, together with the known compounds 2α,3β,5α,7β, 15β-pentaacetoxy-9α-nicotinoyloxyjatropha-6(17),11-dien-14-one (7), salicinolide (8), and euphosalicin (9). The structures and relative configuration of 1 - 6 were established on the basis of extensive spectroscopic analysis, including HRESIMS and one- and two-dimensional NMR techniques. All these compounds, together with diterpenes (10 - 14) isolated previously from this plant, were evaluated for their antiproliferative activity against HeLa, Ishikawa, and MCF7 cells. The multi rug-resistance-reversing activities were also investigated on L5178 mouse lymphoma cells transfected with the pHa MDR1/A retrovirus DNA. Preliminary structure - activity relationship data are discussed.

Original languageEnglish
Pages (from-to)1453-1461
Number of pages9
JournalJournal of Natural Products
Volume74
Issue number6
DOIs
Publication statusPublished - Jun 24 2011

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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