IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

Zsuzsanna Dosztányi, Veronika Csizmok, Peter Tompa, István Simon

Research output: Contribution to journalArticle

1296 Citations (Scopus)

Abstract

Summary: Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that IUP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions. Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.

Original languageEnglish
Pages (from-to)3433-3434
Number of pages2
JournalBioinformatics
Volume21
Issue number16
DOIs
Publication statusPublished - Aug 15 2005

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ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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