Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise

Jaap Fransen, Sindhu R. Johnson, Frank Van Den Hoogen, Murray Baron, Yannick Allanore, Patricia E. Carreira, László Czirják, Christopher P. Denton, Oliver Distler, Daniel E. Furst, Armando Gabrielli, Ariane Herrick, Murat Inanc, Bashar Kahaleh, Otylia Kowal-Bielecka, Thomas A. Medsger, Ulf Mueller-Ladner, Gabriela Riemekasten, Stanislaw Sierakowski, Gabriele ValentiniDoug Veale, Madelon C. Vonk, Ulrich Walker, Lorinda Chung, Philip J. Clements, David H. Collier, Mary E. Csuka, Sergio Jimenez, Peter A. Merkel, James R. Seibold, Richard Silver, Virginia Steen, Alan Tyndall, Marco Matucci-Cerinic, Janet E. Pope, Dinesh Khanna

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective. Classification criteria for systemic sclerosis (SSc; scleroderma) are being updated. Our objective was to select a set of items potentially useful for the classification of SSc using consensus procedures, including the Delphi and nominal group techniques (NGT). Methods. Items were identified through 2 independent consensus exercises performed by the Scleroderma Clinical Trials Consortium and the European League Against Rheumatism Scleroderma Trials and Research Group. The first-round items from both exercises were collated and redundancies were removed, leaving 168 items. A 3-round Delphi exercise was performed using a 1-9 scale (where 1 = completely inappropriate and 9 = completely appropriate) and a consensus meeting using NGT was conducted. During the last Delphi round, the items were ranked on a 1-10 scale. Results. In round 1, 106 experts rated the 168 items. Those with a median score of <4 were removed, resulting in a list of 102 items. In round 2, the items were again rated for appropriateness and subjected to a consensus meeting using NGT by European and North American SSc experts (n = 16), resulting in 23 items. In round 3, SSc experts (n = 26) then individually scored each of the 23 items in a last Delphi round using an appropriateness score (1-9) and ranking their 10 most appropriate items for the classification of SSc. Presence of skin thickening, SSc-specific autoantibodies, abnormal nailfold capillary pattern, and Raynaud's phenomenon ranked highest in the final list that also included items indicating internal organ involvement. Conclusion. The Delphi exercise and NGT resulted in a set of 23 items for the classification of SSc that will be assessed for their discriminative properties in a prospective study.

Original languageEnglish
Pages (from-to)351-357
Number of pages7
JournalArthritis care & research
Volume64
Issue number3
DOIs
Publication statusPublished - Mar 2012

ASJC Scopus subject areas

  • Rheumatology

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    Fransen, J., Johnson, S. R., Van Den Hoogen, F., Baron, M., Allanore, Y., Carreira, P. E., Czirják, L., Denton, C. P., Distler, O., Furst, D. E., Gabrielli, A., Herrick, A., Inanc, M., Kahaleh, B., Kowal-Bielecka, O., Medsger, T. A., Mueller-Ladner, U., Riemekasten, G., Sierakowski, S., ... Khanna, D. (2012). Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise. Arthritis care & research, 64(3), 351-357. https://doi.org/10.1002/acr.20679