It is time to take timing seriously in clinical genetics

Research output: Contribution to journalReview article

Abstract

Observations made by molecular techniques on the genome along the individuals' lifetime indicate that the genome in somatic cells displays changes at molecular, cellular, and organismal levels. Timing of genetic events leading to somatic mosaicism and gene expression dynamism results in a highly important variable for comprehending the role of genetics in health and disease. Consideration of time in clinical genetics should be enthusiastically invested into research strategy, interpretation of the results, diagnostic routine, and particularly in ethical discussions.

Original languageEnglish
Pages (from-to)1435-1437
Number of pages3
JournalEuropean Journal of Human Genetics
Volume23
Issue number11
DOIs
Publication statusPublished - Oct 1 2015

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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