Isotope effect of optical activity measurements on L-α-alanine

W. Darge, I. Laczkó, W. Thiemann

Research output: Contribution to journalArticle


If an optically active organic substance is labelled in the chirality center with another isotopic species (such as15N for14N) a pronounced variation of rotatory power is predicted. We tried to varify this idea experimentally on L-α-alanine and found an isotope effect of ORD (optical rotatory dispersion). The magnitude of the rotation is mainly dependent on the pH of the solvent. The ratio of the optical activity alanine-14N/alanine-15N is about 1.02. The molecular rotations show a consistently lower ratio but it can be seen that the isotope effect is not only a mass effect.

Original languageEnglish
Pages (from-to)521-526
Number of pages6
JournalJournal of Radioanalytical Chemistry
Issue number2
Publication statusPublished - Sep 1976

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Isotope effect of optical activity measurements on L-α-alanine'. Together they form a unique fingerprint.

  • Cite this