Isoprenaline and the pancreas in dogs

Laura Bennett, A. Pap, S. Naruse, D. F. Magee

Research output: Contribution to journalArticle

Abstract

1 In conscious dogs basal pancreatic secretion per 100 min was significantly reduced by 0.75 μg kg‐1 h‐1 of isoprenaline. The expected spontaneous peaking was seen only after stopping the drug. 2 Following propranolol, the 100‐min pancreatic secretion was less than control but greater than secretion after isoprenaline. The interpeak interval was increased, and the perigee levels (interpeak) were higher than in the controls. Peak protein secretion was unaltered but volume was reduced. 3 Guanethidine did not abolish periodicity but it prolonged the interpeak interval. Protein peaks and 100‐min totals were lower than control and volume perigees higher. 4 It is concluded that β‐adrenoreceptor stimulation inhibits pancreatic secretion. Adrenergic antagonists exert similar inhibitory effects indicating a complex role for the sympathetic nervous system in the control of pancreatic secretion.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalJournal of Autonomic Pharmacology
Volume9
Issue number6
DOIs
Publication statusPublished - Jan 1 1989

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Isoproterenol
Pancreas
Dogs
Guanethidine
Adrenergic Antagonists
Sympathetic Nervous System
Periodicity
Propranolol
Proteins
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

Cite this

Isoprenaline and the pancreas in dogs. / Bennett, Laura; Pap, A.; Naruse, S.; Magee, D. F.

In: Journal of Autonomic Pharmacology, Vol. 9, No. 6, 01.01.1989, p. 379-385.

Research output: Contribution to journalArticle

Bennett, Laura ; Pap, A. ; Naruse, S. ; Magee, D. F. / Isoprenaline and the pancreas in dogs. In: Journal of Autonomic Pharmacology. 1989 ; Vol. 9, No. 6. pp. 379-385.
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