Isolation and structure elucidation, molecular docking studies of screlotiumol from soil borne fungi Screlotium rolfsii and their reversal of multidrug resistance in mouse lymphoma cells

Bashir Ahmad, Muhammad Rizwan, Abdur Rauf, Muslim Raza, Sadiq Azam, Shumaila Bashir, Joseph Molnar, Akos Csonka, Diana Szabo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer.

Original languageEnglish
Pages (from-to)2083-2087
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume17
Issue number4
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • MDR
  • Molecular docking
  • Screlotium rolfsii
  • Screlotiumol 1
  • Soil borne fungi

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

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