Isolation and structure determination of antiproliferative secondary metabolites from the potato earthball mushroom, Scleroderma bovista (Agaricomycetes)

Bernadett Kovács, Zoltán Béni, Miklós Dékány, Noémi Bózsity, I. Zupkó, J. Hohmann, Attila Ványolós

Research output: Contribution to journalArticle

Abstract

Mycochemical examination of a methanol extract of Scleroderma bovista Fr. (Agaricomycetes) led to the isolation of 7 compounds, which were, to our knowledge, identified for the first time in this species. The chemical structures of these compounds were determined through extensive spectroscopic methods (nuclear magnetic resonance and mass spectrometry). The fungal metabolites were identified as steroids based on ergostane (compounds 1-4) and lanostane (compounds 6 and 7) skeletons, whereas compound 5 was a ceramide derivative. We evaluated the antiproliferative activity of compounds 4-7 against human cancer cell lines (HeLa, A2780, MDA-MB-231, and MCF-7) using the MTT assay. The lanostane-type derivatives (compounds 6 and 7) and ergosterol peroxide 3-glucoside (compound 4) exerted significant antiproliferative property on 1 or more human cancer cell lines.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalInternational Journal of Medicinal Mushrooms
Volume20
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Agaricales
Solanum tuberosum
Cell Line
Ceramides
Glucosides
Skeleton
Methanol
Mass Spectrometry
Neoplasms
Magnetic Resonance Spectroscopy
Steroids
ergostane
ergosterol-5,8-peroxide

Keywords

  • Antiproliferative activity
  • Ceramide
  • Ergostane and lanostane steroids
  • Medicinal mushrooms
  • Scleroderma bovista

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

Cite this

Isolation and structure determination of antiproliferative secondary metabolites from the potato earthball mushroom, Scleroderma bovista (Agaricomycetes). / Kovács, Bernadett; Béni, Zoltán; Dékány, Miklós; Bózsity, Noémi; Zupkó, I.; Hohmann, J.; Ványolós, Attila.

In: International Journal of Medicinal Mushrooms, Vol. 20, No. 5, 01.01.2018, p. 411-418.

Research output: Contribution to journalArticle

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