Isolation and structural determination of new metabolites from Artemisia asiatica roots

Annamária Zana, Zsuzsanna Hajdú, Nikoletta Jedlinszki, Imre Máthé, György Dombi, Judit Hohmann

Research output: Contribution to journalArticle

Abstract

Two new 2,2-dimethyl-chromene derivatives and the new pentaisovaleryl sucrose were isolated from the roots of Artemisia asiatica together with the known 1-(5-acetyl-2,4-dihydroxy-phenyl)-3-methyl-butan-1-one, 6-hydroxytremetone and (E)-coniferyl aldehyde. The structures of the compounds were elucidated by extensive 1D (1H, 13C and JMOD) and 2D (1H-1H COSY, HSQC, HMBC and NOESY) NMR studies and APCIMS and HRESIMS investigations. 6-Acetyl-3,7-dihydroxy-2,2-dimethyl-chromene and 6-acetyl-3-hydroxy-2,2-dimethyl-chromene are biogenetically related to 1-(5-acetyl-2,4-dihydroxy-phenyl)-3-methyl-butan-1-one and 6-hydroxytremetone as all having isoprenoid acetophenone origin. All the isolated compounds were described for the first time from this species; interestingly none of them are related to the metabolites identified from the extracts of the aerial part of the plant.

Original languageEnglish
Pages (from-to)4817-4820
Number of pages4
JournalTetrahedron
Volume71
Issue number29
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Acetophenone
  • Artemisia asiatica
  • Asteraceae
  • Chromene
  • Sucrose polyester

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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