Isolated glucocorticoid deficiency: metabolic and endocrine studies in a 5-year-old boy

G. Soltész, M. J. Dillon, P. A. Jenkins, A. Moore, A. Aynsley-Green

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A 5-year-old boy is described who presented with episodes of hypoglycaemia triggered by mild infections or fever. Subnormal glucocorticoid production was confirmed by demonstrating low urinary excretion of free cortisol, low plasma cortisol concentrations that did not rise after glucagon and ACTH stimulation, and by elevated plasma ACTH levels. The selective nature of the abnormality was confirmed by demonstrating normal plasma electrolyte concentrations and blood pressure on a salt-restricted diet. Plasma renin activity and plasma aldosterone levels were also normal and responded appropriately to salt restriction and to frusemide-induced diuresis. Starvation-induced hypoglycaemia was associated with raised levels of blood ketone bodies and low blood alanine concentrations. Catecholamine secretion during hypoglycaemia was reduced. Glucocorticoid replacement therapy was effective in restoring normal glucose homeostasis.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalEuropean Journal of Pediatrics
Volume143
Issue number4
DOIs
Publication statusPublished - Mar 1985

Fingerprint

Glucocorticoids
Hypoglycemia
Adrenocorticotropic Hormone
Hydrocortisone
Salts
Ketone Bodies
Diuresis
Furosemide
Starvation
Aldosterone
Glucagon
Renin
Alanine
Electrolytes
Catecholamines
Homeostasis
Fever
Diet
Blood Pressure
Glucose

Keywords

  • ACTH
  • Aldosterone
  • Glucocorticoid deficiency
  • Hypoglycaemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Isolated glucocorticoid deficiency : metabolic and endocrine studies in a 5-year-old boy. / Soltész, G.; Dillon, M. J.; Jenkins, P. A.; Moore, A.; Aynsley-Green, A.

In: European Journal of Pediatrics, Vol. 143, No. 4, 03.1985, p. 297-300.

Research output: Contribution to journalArticle

Soltész, G. ; Dillon, M. J. ; Jenkins, P. A. ; Moore, A. ; Aynsley-Green, A. / Isolated glucocorticoid deficiency : metabolic and endocrine studies in a 5-year-old boy. In: European Journal of Pediatrics. 1985 ; Vol. 143, No. 4. pp. 297-300.
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