Isoenzyme selective phosphoinositide 3-kinase inhibition: What do the stones kill?

László Buday, Szabolcs Sipeki

Research output: Contribution to journalArticle

Abstract

Signalling from receptor tyrosine kinases is presumably the most investigated pathway so far and myriad of protein components and respective interactions involved have been outlined. Considerably, disconcerted receptor tyrosine kinase signalling has been implicated in the generation and maintenance of many different human diseases. The two crucial interlinked axes in receptor tyrosine kinase signalling have received immense attention as therapeutic targets. One contains the Ras activated Raf kinases and their object kinase cascade, the other involves phosphoinositide 3-kinase (PI3K) and downstream targets like the protein kinase Akt (also known as protein kinase B). The PI3K pathway regulates various cellular functions such as proliferation, survival, migration and metabolism. Small molecule PI3K inhibitors with isoenzyme selectivity have been developed in growing number and used as tools to elucidate the isoenzyme specific functions. The pharmacological inhibitors assayed for potentials as therapeutic agents in the treatment of diseases as diverse as cancer, leukaemia, thrombosis and allergic response in different model systems presented promising and also some unexpected results.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalCurrent Signal Transduction Therapy
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 1 2011

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Keywords

  • Cancer
  • Insulin signalling
  • Isoenzymes
  • Leukaemia
  • Phosphoinositide 3-kinase
  • Thrombosis

ASJC Scopus subject areas

  • Endocrinology
  • Pharmacology (medical)

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