Islet Transplantation: Lessons Learned Since the Edmonton Breakthrough

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Abstract

This work sought to summarize the main issues of the last decade in the field of clinical islet transplantation. Ten years ago in Edmonton, a new protocol initiated for islet transplantation brought a breakthrough to the field. The earlier, rather poor results were in a sharp contrast to the first published results of 100% insulin freedom at 1 year. However, later it became clear that the promising initial results decline with time; at around 5 years, only about 10% of the patients maintain freedom from external insulin. Despite that fact, a milestone was set and intensive research started worldwide. New hopes were raised for patients. Modifications of the original protocol have been implemented to improve clinical results; however, islet transplantation remains an experimental procedure to date.

Original languageEnglish
Pages (from-to)1421-1424
Number of pages4
JournalTransplantation proceedings
Volume42
Issue number5
DOIs
Publication statusPublished - Jun 1 2010

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

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