Iscom (immunostimulating complex) vaccines containing mono- or polyvalent pili of enterotoxigenic E. coli; immune response of rabbit and swine.

B. Nagy, S. Höglund, B. Morein

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Iscom (immunostimulating complex) vaccines were prepared to contain K88ab, K88ac, K99 and 987P pili (fimbriae) of enterotoxigenic E. coli bacteria as monovalent or quadrivalent preparations. The iscoms injected into rabbits and into pigs elicited similar or higher immune response in both animal species than the oil adjuvanted vaccine containing about 5 times more of the same pilus protein. It is concluded that inclusion of pili into iscoms results in immunogenic preparations likely worth pursuing for vaccine production against enterotoxic colibacillosis of newborn pigs. The iscoms did not induce local reaction at the injection sites in contrast to the oil adjuvanted vaccines.

Original languageEnglish
Pages (from-to)728-738
Number of pages11
JournalZentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B
Volume37
Issue number10
Publication statusPublished - Dec 1990

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ISCOMs
Enterotoxigenic Escherichia coli
enterotoxigenic Escherichia coli
fimbriae
Swine
Vaccines
rabbits
immune response
vaccines
Rabbits
swine
Oils
oils
injection site
neonates
Bacteria
Injections
bacteria
animals
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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AU - Morein, B.

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