Ischemia reperfusion injury of the skeletal muscle after selective deafferentation

Béla Turchányi, B. Tóth, I. Rácz, Z. Vendégh, J. Furész, J. Hamar

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The present study analyzes the effect of selective deafferentation on the reperfusion injury of the skeletal muscle when nociceptive sensory fibers of the left sciatic nerve are selectively damaged by capsaicin pretreatment in a rat model following tourniquet ischemia (ISC) applied for 30 min, 1 h, and 2 h on the left hind limb. The isometric tetanic contractile force of the extensor digitorum longus (EDL) muscle was measured after 1 h, and 1, 3, or 7 days of reperfusion. Contractile force of the damaged muscle was compared to the intact contralateral muscle. In another group, ISC was used without capsaicin pre-treatment. After 30 min of ISC, there was no difference between deafferented and non-pretreated groups. Following 1 h ISC, with the exception of 1 h reperfusion, the non-pretreated group produced stronger contractions than the deafferented group. After 2 h ISC, the contractile force of the deafferented muscle was significantly stronger compared to the non-deafferented muscle force at all reperfusion times. In conclusions, it was found that the absence of peptidergic sensory fibers after long-lasting (2 h) ischemia is beneficial in reperfusion injury, whereas the absence of vasodilator peptides has unfavorable effects if tissue damage is milder (after 1 h ischemia).

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalPhysiological Research
Volume54
Issue number1
Publication statusPublished - 2005

Fingerprint

Reperfusion Injury
Skeletal Muscle
Ischemia
Muscles
Reperfusion
Capsaicin
Tourniquets
Sciatic Nerve
Vasodilator Agents
Extremities
Peptides

Keywords

  • Capsaicin
  • Muscle contraction
  • Neurogenic inflammation
  • Rat
  • Sensory afferents

ASJC Scopus subject areas

  • Physiology

Cite this

Turchányi, B., Tóth, B., Rácz, I., Vendégh, Z., Furész, J., & Hamar, J. (2005). Ischemia reperfusion injury of the skeletal muscle after selective deafferentation. Physiological Research, 54(1), 25-31.

Ischemia reperfusion injury of the skeletal muscle after selective deafferentation. / Turchányi, Béla; Tóth, B.; Rácz, I.; Vendégh, Z.; Furész, J.; Hamar, J.

In: Physiological Research, Vol. 54, No. 1, 2005, p. 25-31.

Research output: Contribution to journalArticle

Turchányi, B, Tóth, B, Rácz, I, Vendégh, Z, Furész, J & Hamar, J 2005, 'Ischemia reperfusion injury of the skeletal muscle after selective deafferentation', Physiological Research, vol. 54, no. 1, pp. 25-31.
Turchányi B, Tóth B, Rácz I, Vendégh Z, Furész J, Hamar J. Ischemia reperfusion injury of the skeletal muscle after selective deafferentation. Physiological Research. 2005;54(1):25-31.
Turchányi, Béla ; Tóth, B. ; Rácz, I. ; Vendégh, Z. ; Furész, J. ; Hamar, J. / Ischemia reperfusion injury of the skeletal muscle after selective deafferentation. In: Physiological Research. 2005 ; Vol. 54, No. 1. pp. 25-31.
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