Isatin (Indole-2, 3-dione) inhibits natriuretic peptide-induced hyperthermia in rats

Imre Pataki, Ágnes Adamik, Gyula Telegdy

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effects of an endogenous indole, isatin (indole-2, 3-dione), on the hyperthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 μg caused elevations in colon temperature 30 and 60 min after injection. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possible involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hyperthermic effect in vivo.

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalPeptides
Volume21
Issue number3
DOIs
Publication statusPublished - Mar 2000

Keywords

  • Hyperthermia
  • Isatin
  • Natriuretic peptide
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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