Is there any connection between the presence of kidney stones in primary hyperparathyroidism and the location of an underlying adenoma?

Emoke Csupor, E. Toth, S. Meszaros, V. Ferencz, J. Szucs, P. Lakatos, J. Horányi, F. Perner, C. Horváth

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The majority of the patients with primary hyperparathyroidism (pHPT) recurrently produce kidney stones, while the rest have other clinical manifestations. The aim of this study was to examine the possibility of an association between the presence of kidney stones and the location of an underlying adenoma. This was a retrospective evaluation of the records of 91 patients (10 males, 81 females, mean age: 61.9 years [20-70 yrs]) operated for primary hyperparathyroidism between 1995 and 2000. One patient was excluded due to carcinoma. Kidney stones were found in 55 cases and other clinical symptoms in 35 cases. In 50 of the 55 patients (91%) with kidney stones, the adenoma was located in the left inferior parathyroid gland (χ2 = 67.5, p <0.00,001), while in 24 of the 35 patients (69%) without kidney stones, the adenoma was in the right inferior parathyroid gland (χ2 = 43.9, p <0.0001). These results suggest that the location of the adenoma may influence the presence of kidney stones in pHPT. It is proposed that the biologic effects of parathyroid hormone could differ depending on which of the four parathyroid glands it was secreted in, or the four glands may produce different biologically active fragments.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalExperimental and Clinical Endocrinology and Diabetes
Volume113
Issue number5
DOIs
Publication statusPublished - May 2005

Fingerprint

Kidney Calculi
Primary Hyperparathyroidism
Adenoma
Parathyroid Glands
Parathyroid Hormone
Carcinoma

Keywords

  • Kidney stones
  • Location of adenoma
  • Primary hyperparathyroidism

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Is there any connection between the presence of kidney stones in primary hyperparathyroidism and the location of an underlying adenoma? / Csupor, Emoke; Toth, E.; Meszaros, S.; Ferencz, V.; Szucs, J.; Lakatos, P.; Horányi, J.; Perner, F.; Horváth, C.

In: Experimental and Clinical Endocrinology and Diabetes, Vol. 113, No. 5, 05.2005, p. 257-261.

Research output: Contribution to journalArticle

@article{957c86e883fa45249d9478f0ec48c1d7,
title = "Is there any connection between the presence of kidney stones in primary hyperparathyroidism and the location of an underlying adenoma?",
abstract = "The majority of the patients with primary hyperparathyroidism (pHPT) recurrently produce kidney stones, while the rest have other clinical manifestations. The aim of this study was to examine the possibility of an association between the presence of kidney stones and the location of an underlying adenoma. This was a retrospective evaluation of the records of 91 patients (10 males, 81 females, mean age: 61.9 years [20-70 yrs]) operated for primary hyperparathyroidism between 1995 and 2000. One patient was excluded due to carcinoma. Kidney stones were found in 55 cases and other clinical symptoms in 35 cases. In 50 of the 55 patients (91{\%}) with kidney stones, the adenoma was located in the left inferior parathyroid gland (χ2 = 67.5, p <0.00,001), while in 24 of the 35 patients (69{\%}) without kidney stones, the adenoma was in the right inferior parathyroid gland (χ2 = 43.9, p <0.0001). These results suggest that the location of the adenoma may influence the presence of kidney stones in pHPT. It is proposed that the biologic effects of parathyroid hormone could differ depending on which of the four parathyroid glands it was secreted in, or the four glands may produce different biologically active fragments.",
keywords = "Kidney stones, Location of adenoma, Primary hyperparathyroidism",
author = "Emoke Csupor and E. Toth and S. Meszaros and V. Ferencz and J. Szucs and P. Lakatos and J. Hor{\'a}nyi and F. Perner and C. Horv{\'a}th",
year = "2005",
month = "5",
doi = "10.1055/s-2005-837553",
language = "English",
volume = "113",
pages = "257--261",
journal = "Experimental and Clinical Endocrinology and Diabetes",
issn = "0947-7349",
publisher = "Thieme",
number = "5",

}

TY - JOUR

T1 - Is there any connection between the presence of kidney stones in primary hyperparathyroidism and the location of an underlying adenoma?

AU - Csupor, Emoke

AU - Toth, E.

AU - Meszaros, S.

AU - Ferencz, V.

AU - Szucs, J.

AU - Lakatos, P.

AU - Horányi, J.

AU - Perner, F.

AU - Horváth, C.

PY - 2005/5

Y1 - 2005/5

N2 - The majority of the patients with primary hyperparathyroidism (pHPT) recurrently produce kidney stones, while the rest have other clinical manifestations. The aim of this study was to examine the possibility of an association between the presence of kidney stones and the location of an underlying adenoma. This was a retrospective evaluation of the records of 91 patients (10 males, 81 females, mean age: 61.9 years [20-70 yrs]) operated for primary hyperparathyroidism between 1995 and 2000. One patient was excluded due to carcinoma. Kidney stones were found in 55 cases and other clinical symptoms in 35 cases. In 50 of the 55 patients (91%) with kidney stones, the adenoma was located in the left inferior parathyroid gland (χ2 = 67.5, p <0.00,001), while in 24 of the 35 patients (69%) without kidney stones, the adenoma was in the right inferior parathyroid gland (χ2 = 43.9, p <0.0001). These results suggest that the location of the adenoma may influence the presence of kidney stones in pHPT. It is proposed that the biologic effects of parathyroid hormone could differ depending on which of the four parathyroid glands it was secreted in, or the four glands may produce different biologically active fragments.

AB - The majority of the patients with primary hyperparathyroidism (pHPT) recurrently produce kidney stones, while the rest have other clinical manifestations. The aim of this study was to examine the possibility of an association between the presence of kidney stones and the location of an underlying adenoma. This was a retrospective evaluation of the records of 91 patients (10 males, 81 females, mean age: 61.9 years [20-70 yrs]) operated for primary hyperparathyroidism between 1995 and 2000. One patient was excluded due to carcinoma. Kidney stones were found in 55 cases and other clinical symptoms in 35 cases. In 50 of the 55 patients (91%) with kidney stones, the adenoma was located in the left inferior parathyroid gland (χ2 = 67.5, p <0.00,001), while in 24 of the 35 patients (69%) without kidney stones, the adenoma was in the right inferior parathyroid gland (χ2 = 43.9, p <0.0001). These results suggest that the location of the adenoma may influence the presence of kidney stones in pHPT. It is proposed that the biologic effects of parathyroid hormone could differ depending on which of the four parathyroid glands it was secreted in, or the four glands may produce different biologically active fragments.

KW - Kidney stones

KW - Location of adenoma

KW - Primary hyperparathyroidism

UR - http://www.scopus.com/inward/record.url?scp=20944446875&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20944446875&partnerID=8YFLogxK

U2 - 10.1055/s-2005-837553

DO - 10.1055/s-2005-837553

M3 - Article

C2 - 15926110

AN - SCOPUS:20944446875

VL - 113

SP - 257

EP - 261

JO - Experimental and Clinical Endocrinology and Diabetes

JF - Experimental and Clinical Endocrinology and Diabetes

SN - 0947-7349

IS - 5

ER -