Is the saccharide component of the insulin receptor involved in hormonal imprinting?

P. Kovács, G. Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hormonal imprinting takes place at the first interaction of a given hormone with the cell (the Tetrahymena in the present case) and accounts for a greater responsiveness to the hormone on re‐exposure(s). The Tetrahymena is able to bind insulin and Concanavalin‐A (Con‐A) as well. Exposure to both ligands—simultaneously or in sequence—enhances the binding of both in the progeny generations. It follows that the lectin, which inhibits insulin binding by direct action, enhances rather than depresses the effect of insulin‐induced imprinting.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalCell biochemistry and function
Volume4
Issue number2
DOIs
Publication statusPublished - Apr 1986

Keywords

  • Conacanavalin‐A
  • Insulin receptor
  • hormonal imprinting
  • unicellular model system

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

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