Primer antifoszfolipid szindróma: A szisztémás lupus erythematosus elofutára?

Translated title of the contribution: Is the primary antiphospholipid syndrome a forerunner of SLE?

Tünde Tarr, Györgyi Muzes, Ervin Pitlik, Gabriella Lakos, Tünde Csépány, Pál Soltész, Margit Zeher, Gyula Szegedi, Emese Kiss

Research output: Contribution to journalReview article

1 Citation (Scopus)


Introduction: Antiphospholipid syndrome is a multi-organ autoimmune disorder, characterized by arterial and venous thrombotic events, and a well-defined group of recurrent foetal wasteage due to pathologic antibodies against phospholipids and protein co-factors. Antiphospholipid antibodies can be formed in primary antiphospholipid syndrome, but also in other conditions, most often in systemic lupus erythematosus. This may modify the outcome of lupus increasing the risk for thrombotic complications. Less is known about the outcome in primary antiphospholipid syndrome, whether it may precede the development of systemic lupus. Aims: Authors hereby describe the case of four patients with primary antiphospholipid syndrome in whom the disease progressed to systemic lupus erythematosus. Results: Lupus followed the primary antiphospholipid syndrome within around a three-year period. It was indicated by the appearance of different antinuclear autoantibodies and clinical complications, such as polyarthritis, nephritis and hematologic disturbances. All of the patients presented cerebrovascular accident as the thrombotic manifestation. All but one, were around forty years old, and had a milder form of lupus. Symptoms of the antiphospholipid syndrome determined the outcome. On the other hand, a typical lupus developed in the youngest patient. Conclusions: According to present cases antiphospholipid syndrome may be considered as the initiative phase of SLE, but APS being a separate entity also may associate to lupus. Present observations indicate the importance of follow-up the patients with APS by immunologic respect. Future prospective, multi-centre studies with larger number of cases are needed to provide further evidence on the fact that patients with APS may acquire other autoimmune disorder.

Translated title of the contributionIs the primary antiphospholipid syndrome a forerunner of SLE?
Original languageHungarian
Pages (from-to)203-207
Number of pages5
JournalOrvosi hetilap
Issue number5
Publication statusPublished - Dec 1 2005

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Is the primary antiphospholipid syndrome a forerunner of SLE? A szisztémás lupus erythematosus elofutára?'. Together they form a unique fingerprint.

  • Cite this