Is the mouse a good model of human PPARγ-related metabolic diseases?

Attila Pap, Ixchelt Cuaranta-Monroy, Matthew Peloquin, L. Nagy

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

With the increasing number of patients affected with metabolic diseases such as type 2 diabetes, obesity, atherosclerosis and insulin resistance, academic researchers and pharmaceutical companies are eager to better understand metabolic syndrome and develop new drugs for its treatment. Many studies have focused on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ), which plays a crucial role in adipogenesis and lipid metabolism. These studies have been able to connect this transcription factor to several human metabolic diseases. Due to obvious limitations concerning experimentation in humans, animal models—mainly mouse models-have been generated to investigate the role of PPARγ in different tissues. This review focuses on the metabolic features of human and mouse PPARγ -related diseases and the utility of the mouse as a model.

Original languageEnglish
Article number1236
JournalInternational Journal of Molecular Sciences
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

metabolic diseases
PPAR gamma
Metabolic Diseases
mice
Human Experimentation
Adipogenesis
Transcription factors
lipid metabolism
Insulin
obesity
Cytoplasmic and Nuclear Receptors
Medical problems
Lipid Metabolism
arteriosclerosis
Pharmaceutical Preparations
Drug products
Type 2 Diabetes Mellitus
insulin
Insulin Resistance
Atherosclerosis

Keywords

  • Human mutations
  • Ligand activation
  • Lipodystrophy
  • Metabolic syndrome
  • Mouse models
  • PPARγ expression

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Is the mouse a good model of human PPARγ-related metabolic diseases? / Pap, Attila; Cuaranta-Monroy, Ixchelt; Peloquin, Matthew; Nagy, L.

In: International Journal of Molecular Sciences, Vol. 17, No. 8, 1236, 01.08.2016.

Research output: Contribution to journalReview article

Pap, Attila ; Cuaranta-Monroy, Ixchelt ; Peloquin, Matthew ; Nagy, L. / Is the mouse a good model of human PPARγ-related metabolic diseases?. In: International Journal of Molecular Sciences. 2016 ; Vol. 17, No. 8.
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