Is the knife-cut in the hypothalamus a permanent barrier to regrowth of nerve fibers?-an affirmative answer

L. Nagy, K. Köves, M. Réthelyi, B. Halász

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The regenerative capacity of nerve fibers was studied in adult female rats. Horseradish peroxidase was injected into the anterior hypothalamus lateral to the suprachiasmatic nucleus 4 days, 6 weeks and 4 months, respectively, following an archiform retrochiasmatic knife-cut. The trajectory of the stained fibers was examined on horizontal sections of the hypothalamus. No nerve fibers could be seen sprouting across the scar-tissue of the knife-cut regardless of the survival time. In one rat (6-week survival time) a bundle of fine nerve fibers turned in a medial direction at the caudal end of the knife-cut, suggesting that sprouting fibers were destined to reinnervate parts of the deafferented medial-basal hypothalamus.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalBrain Research
Volume268
Issue number2
DOIs
Publication statusPublished - Jun 6 1983

Fingerprint

Nerve Fibers
Hypothalamus
Middle Hypothalamus
Anterior Hypothalamus
Suprachiasmatic Nucleus
Horseradish Peroxidase
Cicatrix

Keywords

  • deafferented hypothalamus
  • rat
  • reinnervation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Is the knife-cut in the hypothalamus a permanent barrier to regrowth of nerve fibers?-an affirmative answer. / Nagy, L.; Köves, K.; Réthelyi, M.; Halász, B.

In: Brain Research, Vol. 268, No. 2, 06.06.1983, p. 354-358.

Research output: Contribution to journalArticle

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