Is the knife-cut in the hypothalamus a permanent barrier to regrowth of nerve fibers?-an affirmative answer

L. Nagy, Katalin Köves, M. Réthelyi, B. Halász

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21 Citations (Scopus)


The regenerative capacity of nerve fibers was studied in adult female rats. Horseradish peroxidase was injected into the anterior hypothalamus lateral to the suprachiasmatic nucleus 4 days, 6 weeks and 4 months, respectively, following an archiform retrochiasmatic knife-cut. The trajectory of the stained fibers was examined on horizontal sections of the hypothalamus. No nerve fibers could be seen sprouting across the scar-tissue of the knife-cut regardless of the survival time. In one rat (6-week survival time) a bundle of fine nerve fibers turned in a medial direction at the caudal end of the knife-cut, suggesting that sprouting fibers were destined to reinnervate parts of the deafferented medial-basal hypothalamus.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalBrain research
Issue number2
Publication statusPublished - Jun 6 1983



  • deafferented hypothalamus
  • rat
  • reinnervation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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