In the present study, we investigated the possible implication of plasma or brain ANP in the development of hypertension of SHR with altered calcium homeostasis after various calcium diets and parathyroidectomy. In our study, the decreased ANP levels in the hypothalamus parallel the decreased calcium concentration in serum. One may speculate that there is a link between an altered calcium homeostasis and changes of hypothalamic ANP concentration in the pathogenesis of rat spontaneous hypertension. This hypothesis is supported by the observation that chronic infusion of low doses of ANP reduces blood pressure in conscious SHR, pointing to ANP being involved in the development and maintenance of high blood pressure in SHR. This study indicates that ANP in the plasma and hypothalamus plays an important role in regulating blood pressure and fluid balance under the condition of altered calcium intake and PTH status.
|Issue number||SUPPL. 25|
|Publication status||Published - Jan 1 1988|
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