Is Radical Nephroureterectomy and Lymph Node Dissection Necessary for Upper-tract TCC?

S. Joniau, B. Van Cleynenbreugel, W. Blyweert, I. Romics, H. Van Poppel

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Upper urinary tract transitional cell carcinoma (UUTT) is a rare condition, and there are no internationally validated guidelines on how to treat these lesions. Invasive and metastatic disease is more common than in bladder transitional cell carcinoma (TCC). Ureteroscopy with biopsy and computed tomography (CT) urography add diagnostic accuracy; however, in high-grade lesions, muscle invasion and lymph nodes may be missed in 10-40% of the cases. Open nephroureterectomy (NU) remains the gold standard against which other approaches should be compared. Laparoscopic NU is becoming widely accepted as a minimally invasive alternative, delivering similar oncologic outcomes at short or intermediate follow-up. For low-stage, low-grade lesions, for solitary lesions and in imperative indications, nephron-sparing surgery (NSS) may be offered to the patient. The role of lymphadenectomy lies in correct staging, and its therapeutic benefit remains controversial. Ideally, large international, prospective trials should assess the best management of UUTT.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalEuropean Urology, Supplements
Volume9
Issue number3
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Transitional Cell Carcinoma
Lymph Node Excision
Urinary Tract
Ureteroscopy
Urography
Nephrons
Urinary Bladder
Lymph Nodes
Tomography
Guidelines
Biopsy
Muscles
Therapeutics

Keywords

  • Lymph node dissection
  • Nephroureterectomy
  • Transitional cell carcinoma
  • Upper-tract

ASJC Scopus subject areas

  • Urology

Cite this

Is Radical Nephroureterectomy and Lymph Node Dissection Necessary for Upper-tract TCC? / Joniau, S.; Van Cleynenbreugel, B.; Blyweert, W.; Romics, I.; Van Poppel, H.

In: European Urology, Supplements, Vol. 9, No. 3, 04.2010, p. 442-445.

Research output: Contribution to journalArticle

Joniau, S. ; Van Cleynenbreugel, B. ; Blyweert, W. ; Romics, I. ; Van Poppel, H. / Is Radical Nephroureterectomy and Lymph Node Dissection Necessary for Upper-tract TCC?. In: European Urology, Supplements. 2010 ; Vol. 9, No. 3. pp. 442-445.
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